Head of the Department: Doctor of Chemical Sciences, Professor D. M. Volochnyuk
Head of the Department
Doctor of Chemical Sciences, Professor D. M. Volochnyuk

The department was established in 1958 by Professor P. S. Pelkis, who headed it until 1980. Since 2011, the department has been led by Doctor of Chemical Sciences, Professor D. M. Volochnyuk. The department employs 2 doctors of science, 11 PhD and a senior engineer.

The main scientific focus of the department is molecular design and the synthesis of compounds for the needs of medicinal and agrochemistry. The department works on lead-oriented synthesis and strategies for diversity-oriented conformational constraint. Additionally, research is conducted on developing methods for synthesizing analogs of natural and biologically active substances containing pharmacophore groups with phosphorus and fluorine atoms.

Major Scientific and Practical Achievements of the Department

The department's staff has developed new medicinal drugs (Ademol, Amben, Mebiphen, Nicorandil, Tomerzol, Yakton), which were created as part of joint projects with institutes of the National Academy of Sciences of Ukraine (Biochemistry; Food Biotechnology and Genomics; Cell Biology and Genetic Engineering) and the National Academy of Medical Sciences of Ukraine (Pharmacology and Toxicology; Experimental and Applied Oncology and Radiology). The department actively participates in various projects with domestic and international partners aimed at discovering new compounds with specific biological properties: "Synthesis of Combinatorial Libraries and Functional Materials" (PJSC "Macrohim"), "Development and Synthesis of New Polyfunctional Building Blocks for Medicinal Chemistry" (BCH Research, United Kingdom), Targeted comprehensive program of fundamental research by the NAS of Ukraine: "Fundamental Problems in the Creation of New Substances and Materials for Chemical Production" (project: "Design and Synthesis of Next-Generation Nitrogen-Containing Bisphosphonates, Investigation of Their Synergy with Vitamin D3 in Treating Bone Tissue Disorders"), State Targeted Scientific and Technical Program for the Development of Advanced Technologies for the Creation of Domestic Medicinal Products to Support Human Health and Meet Veterinary Medicine Needs for 2011–2015, "Development of New Drugs to Combat Human Enterobacterial Infections Based on Heterocyclic Compounds."

Department Staff

  • Head of Department, D.Sc. (Chem.), Prof. Dmytro M. Volochnyuk
  • D.Sc. (Chem.), Assoc. Prof. Serhii P. Ivonin
  • Ph.D. (Chem.), Senior Researcher Ievgen V. Zarudnytskyi
  • Ph.D. (Chem.), Senior Researcher Oleksandr V. Borysov
  • Ph.D. (Chem.), Research Scientist Alina О. Gorlova
  • Ph.D. (Chem.), Junior Research Scientist Oleksandr V. Gaidai
  • Ph.D. (Chem.), Junior Research Scientist Volodymyr I. Bozhanov
  • Ph.D. (Chem.), Junior Research Scientist Andrii I. Subota
  • Ph.D. (Chem.), Engineer Yevhen Y. Slobodyanyuk
  • Ph.D. (Chem.), Lead Engineer Serhii B. Babii
  • Ph.D. (Chem.), Engineer Oleksandr Y. Pashenko
  • Ph.D. (Chem.), Junior Research Scientist Volodymyr V. Voloshchuk
  • Ph.D. (Chem.), Lead Engineer Dmytro V. Yehorov
  • Lead Engineer Liudmyla S. Samoilenko
  • Technician Nina I. Ratushna
  • Engineer Oleksandr S. Shevchenko
  • Engineer Pavlo V. Nedilko
  • Engineer Dmytro P. Bohdan
  • Engineer Oleksandr V. Pyvovarenko

The list of the most significant publications of Department for 2021–2024

  1. Chalyk B.A., Khutorianskyi A.V., Vashchenko B.V., Danyleiko K., Grynyova A., Osipova A.O., Kozytskiy A., Syniuchenko D., Tsymbaliuk A., Gavrilenko K.S., Biitseva A.V., Volochnyuk D.M., Komarov I.V., Grygorenko O.O. Reductive Recyclization of sp3-Enriched Functionalized Isoxazolines into α-Hydroxy Lactams (2022) Journal of Organic Chemistry, 87 (2), pp. 1001 - 1018
  2. Chernykh A.V., Chernykh A.V., Radchenko D.S., Chheda P.R., Rusanov E.B., Grygorenko O.O., Spies M.A., Volochnyuk D.M., Komarov I.V. A stereochemical journey around spirocyclic glutamic acid analogs (2022) Organic and Biomolecular Chemistry, 20 (15), pp. 3183 - 3200
  3. Holovach S., Melnykov K.P., Skreminskiy A., Herasymchuk M., Tavlui O., Aloshyn D., Borysko P., Rozhenko A.B., Ryabukhin S.V., Volochnyuk D.M., Grygorenko O.O. Effect of gem-Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes (2022) Chemistry - A European Journal, 28 (19), art. no. e202200331
  4. Malashchuk A., Demchuk O.P., Razhyk B.V., Holumbievskyi V.O., Kudryk O.V., Chernykh A.V., Hryshchuk O.V., Sosunovych B.S., Volochnyuk D.M., Vashchenko B.V., Grygorenko O.O. 2- and 3-Fluorocyclobutane Building Blocks for Organic and Medicinal Chemistry (2024) European Journal of Organic Chemistry, 27 (32), art. no. e202400493
  5. Zabolotna Y., Volochnyuk D.M., Ryabukhin S.V., Horvath D., Gavrilenko K.S., Marcou G., Moroz Y.S., Oksiuta O., Varnek A. A Close-up Look at the Chemical Space of Commercially Available Building Blocks for Medicinal Chemistry (2022) Journal of Chemical Information and Modeling, 62 (9), pp. 2171 - 2185
  6. Zabolotna Y., Volochnyuk D.M., Ryabukhin S.V., Gavrylenko K., Horvath D., Klimchuk O., Oksiuta O., Marcou G., Varnek A. SynthI: A New Open-Source Tool for Synthon-Based Library Design (2022) Journal of Chemical Information and Modeling, 62 (9), pp. 2151 - 2163
  7. Chalyk B.A., Izhyk V.V., Danyleiko K., Sosunovych B., Vashchenko B.V., Zginnyk O., Olshanska V., Teodorovic P., Biitseva A.V., Volochnyuk D.M., Grygorenko O.O. Synthesis of Spirocyclic and Fused Isoxazoline Building Blocks (2023) European Journal of Organic Chemistry, 26 (22), art. no. e202300282
  8. Yu I.F., Manske J.L., Diéguez-Vázquez A., Misale A., Pashenko A.E., Mykhailiuk P.K., Ryabukhin S.V., Volochnyuk D.M., Hartwig J.F. Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes (2023) Nature Chemistry, 15 (5), pp. 685 - 693
  9. Pashenko A.E., Gaidai A., Hryhoriev N., Volovenko O., Levandovskiy I., Maksymenko O., Volochnyuk D.M., Ryabukhin S.V. Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents (2023) Organic Process Research and Development, 27 (3), pp. 477 - 487
  10. Holovach S., Poroshyn I., Melnykov K.P., Liashuk O.S., Pariiska O.O., Kolotilov S.V., Rozhenko A.B., Volochnyuk D.M., Grygorenko O.O. Parallel Minisci Reaction of gem-Difluorocycloalkyl Building Blocks (2024) ACS Organic and Inorganic Au, 4 (4), pp. 424 - 431
  11. Grygorenko O.O., Volochnyuk D.M., Vashchenko B.V. Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances (2021) European Journal of Organic Chemistry, 2021 (47), pp. 6478 - 6510
  12. Herasymchuk M., Melnykov K.P., Yarmoliuk D.V., Serhiichuk D., Rotar V., Pukhovoi T., Kuchkovska Y.O., Holovach S., Volochnyuk D.M., Ryabukhin S.V., Grygorenko O.O. Last of the gem-Difluorocycloalkanes 2: Synthesis of Fluorinated Cycloheptane Building Blocks (2021) European Journal of Organic Chemistry, 2021 (47), pp. 6561 - 6569
  13. Nicolai J., Fantoni T., Butcher T.W., Arlow S., Ryabukhin S.V., Volochnyuk D.M., Hartwig J.F. Copper-Mediated Cyanodifluoromethylation of (Hetero)aryl Iodides and Activated (Hetero)aryl Bromides with TMSCF2CN (2024) Journal of the American Chemical Society, 146 (22), pp. 15464 - 15472
  14. Zabolotna Y., Lin A., Horvath D., Marcou G., Volochnyuk D.M., Varnek A. Chemography: Searching for Hidden Treasures (2021) Journal of Chemical Information and Modeling, 61 (1), pp. 179 - 188
  15. Platonov M., Maximyuk O., Rayevsky A., Hurmach V., Iegorova O., Naumchyk V., Bulgakov E., Cherninskyi A., Ozheredov D., Ryabukhin S.V., Krishtal O., Volochnyuk D.M. 4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors (2024) International Journal of Molecular Sciences, 25 (7), art. no. 3584
  16. Demchuk O.P., Hryshchuk O.V., Vashchenko B.V., Trofymchuk S.A., Melnykov K.P., Skreminskiy A., Volochnyuk D.M., Grygorenko O.O. Fluoroalkyl-Containing 1,2-Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry (2021) European Journal of Organic Chemistry, 2021 (1), pp. 87 - 95
  17. Slobodyanyuk E.Y., Tarasiuk I., Pasichnyk T., Volochnyuk D.M., Sibgatulin D.O., Grygorenko O.O. (Diazomethyl)dimethylphosphine Oxide – A Diazoalkane Reagent for [3+2] Cycloadditions (2024) Chemistry - A European Journal, 30 (23), art. no. e202303972
  18. Melnykov K.P., Nazar K., Smyrnov O., Skreminskyi A., Pavlenko S., Klymenko-Ulianov O., Shishkina S., Volochnyuk D.M., Grygorenko O.O. Mono- and Difluorinated Saturated Heterocyclic Amines for Drug Discovery: Systematic Study of Their Physicochemical Properties (2023) Chemistry - A European Journal, 29 (47), art. no. e202301383
  19. Chernykh A.V., Kudryk O.V., Olifir O.S., Dobrydnev A.V., Rusanov E., Moskvina V.S., Volochnyuk D.M., Grygorenko O.O. Expanding the Chemical Space of 1,2-Difunctionalized Cyclobutanes (2023) Journal of Organic Chemistry, 88 (5), pp. 3109 - 3131
  20. Fedyk A., Slobodyanyuk E.Y., Stotska O., Vashchenko B.V., Volochnyuk D.M., Sibgatulin D.A., Tolmachev A.A., Grygorenko O.O. Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico-Chemical Properties (2021) European Journal of Organic Chemistry, 2021 (47), pp. 6591 - 6603
  21. Pendiukh V.V., Yakovleva H.V., Stadniy I.A., Pashenko A.E., Rusanov E.B., Grabovaya N.V., Kolotilov S.V., Rozhenko A.B., Ryabukhin S.V., Volochnyuk D.M. Practical Synthetic Method for Amino Acid-Derived Diazoketones Shelf-Stable Reagents for Organic Synthesis (2024) Organic Process Research and Development, 28 (1), pp. 165 - 176
  22. Demchuk O.P., Bobovskyi B.V., Vashchenko B.V., Hryshchuk O.V., Skreminskyi A., Chernykh A.V., Moskvina V.S., Hordiyenko O.V., Volochnyuk D.M., Grygorenko O.O. 3-Fluoroalkyl (CF3, CHF2, CH2F) Cyclobutane-Derived Building Blocks for Medicinal Chemistry: Synthesis and Physicochemical Properties (2023) European Journal of Organic Chemistry, 26 (24), art. no. e202300292
  23. Chernykh A.V., Vashchenko B.V., Shishkina S.V., Volochnyuk D.M., Grygorenko O.O. 3-Substituted 6-Azabicyclo[3.1.1]heptanes: Nonclassical Piperidine Isosteres for Drug Discovery (2024) Journal of Organic Chemistry, 89 (15), pp. 10440 - 10450
  24. Ivonin S.P., Voloshchuk V.V., Rusanov E.B., Suikov S., Ryabukhin S.V., Volochnyuk D.M. Synthesis of 6-azaindoles via formal electrophilic [4 + 1]-cyclization of 3-amino-4-methyl pyridines: new frontiers of diversity (2024) Organic Chemistry Frontiers