The laboratory was founded in 2015 from the staff of the Department of biologically active compounds InFOV named LM Litvinenko NAS of Ukraine.
The Laboratory of Condensed Heterocyclic Systems conducts fundamental research in the field of organic and heterocyclic chemistry - synthesis and properties investigation of new classes of condensed heterocyclic compounds with a central 6- to 8-membered nitrogen-containing heterocyclic ring. The goal is to develop original synthetic methods aimed at creating lead-oriented libraries of functionalized biologically active compounds with high pharmacological potential for modern medical and pharmaceutical chemistry. Compounds with anticonvulsant, antidepressant, anticancer activity, and high activity against the causative agent of leishmaniasis were found among the compounds synthesized by the laboratory staff. The search for useful properties is carried out in cooperation with domestic and foreign scientific institutions.
Main scientific and practical achievements of the department
- Synthesis and reactivity of aryl/hetaryl substituted and condensed (amino)azoles, azines, (di)azepines
- Synthesis of new condensed azaheterocyclic systems with wide possibilities of modification of their structure and further functionality
- Construction of new dinuclear heterocycles with the maximum degree of sp3-saturation and developed three-dimensional structure based on modern concepts regarding the construction of biologically active molecules in the creation of leader compounds.
- Development of methods for the analysis of explosives in contaminated soils.
The Major Scientific and Practical Achievements of the Department
Laboratory researchers have developed methods for the synthesis of isoquinolines, ß-carbolines, cinnolines condensed with pyrrole, pyrazole, and thiophene cores, new 2,3-benzodiazepine derivatives, and other classes of condensed nitrogen-containing heterocycles. The laboratory is one of the research groups that initiated a new direction in the chemistry of heterocyclic compounds - the modern methodology of the Picte-Spengler Reaction.
On the basis of pyrazolo [3,4-c] isoquinoline derivatives, a preparative way of perspective functionalization of the active nucleus of potential leaders of a new class of low-toxic anticancer compounds has been developed.

The cyclizations of 4-aryl- and 4-arylmethyl-substituted aminoazoles, thiophenes and cyclic carbonyl compounds of various structure were investigated. Derivatives of new heterocyclic systems were synthesized for the first time. We discovered C-C bond breaking reactions in spirocyclic compounds leading to further functionalization of heterocycles. Among the obtained compounds, molecules with high activity against leishmaniasis and some types of cancer were found.

The developed approach is extended to the formation of central seven-membered ring in new heterocyclic systems.

For the first time, esters and ketones of the 2,3-benzodiazepine series were synthesized using the Eschenmoser sulfide compression reaction. An effective method for the synthesis of derivatives of the new heterocyclic thieno[2,3-d][2,3]benzodiazepine system was developed.

An original approach to the preparation of sp3-enriched functionalized bicyclic compounds with a 1,2,3-triazole core, based on the use of available commercial reagents, was developed.

Recommendations for sampling and sample preparation of affected soil samples contaminated with explosives and their decomposition products as a result of missile and bomb strikes have been developed. The degree of extraction of nitro compounds was determined on model soil samples, optimization of analysis methods was carried out taking into account the guidelines SW-846-8330 (USA) and ISO 119-16-3_2021. A chromato-mass spectrometric study of model and field soil samples was carried out, optimization of methods for determining explosives was carried out.
Laboratory Staff
- Head of Lab Serhii Bohza Dr.Sci.
- Senior Researcher Natalia Bohdan PhD
- Leading Engineer Oleg Svaljavin PhD
- Junior Researcher Diana Stepanova
- Engineer Serhii Shuvakin
The Most Important Publications of the Laboratory for 2019 – 2024:
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Natalia M. Bohdan, Diana S. Stepanova, Serhii Yu. Suikov, Vadim Yu. Popov, Yuri V. Ishkov, Serhii L. Bohza 1-Aryl-4-(2-oxoalkylsulfanyl)-2,3(5H)-benzodiazepines: synthesis and thiophene ring annulation to 1,2-diazepine core Chemistry of Heterocyclic Compounds 2023, 59(6/7), 508–511
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Carlos Eduardo de Castro Alves, Serge L. Bogza, Nathalie Bohdan, Alexander B. Rozhenko, Alice de Freitas Gomes, Regiane Costa de Oliveira, Renata Galvão de Azevedo, Larissa Raquel Silva Maciel, Anamika Dhyani, Andriy Grafov & Gemilson Soares Pontes Pharmacological assessment of the antineoplastic and immunomodulatory properties of a new spiroindolone derivative (7’,8’-Dimethoxy-1’,3’-dimethyl-1,2,3’,4’-tetrahydrospiro[indole-3,5’-pyrazolo[3,4-c]isoquinolin]-2-one) in chronic myeloid leukemia Investigational New Drugs (2023)
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Amal Amaghnouje, Serhii Bohza, Nathalie Bohdan, Imane Es-Safi, Andrii Kyrylchuk, Sanae Achour, Hinde El Fatemi, Dalila Bousta and Andriy Grafov New 2,3-Benzo¬diazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice MDPI, Pharmaceuticals 2021, 14, 814
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N.M. Bogdan, O.V. Ivanysenko, S.Yu. Sujkov, H.V. Yakovleva , O.M. Shved, S.L. Bogza Simple synthesis of heterocyclic benzo[f]azulene isosters. Construction of a 2-benzazepine fragment in the Pictet—Spengler reaction Reports of the National Academy of Sciences of Ukraine.- 1(2022), 92-98
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EL Moussaoui, A.; Bourhia, M.; Jawhari, F.Z.; Salamatullah, A.M.; Ullah, R.; Bari, A.; Majid Mahmood,H.; Sohaib, M.; Bohza, S., Rozhenko, A., Bousta, D., Bari, A. Chemical Profiling, Antioxidant, and Antimicrobial Activity against Drug-Resistant Microbes of Essential Oil from Withania frutescens L. MDPI, Applied Sciences 2021, 11, 5168
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V. P. Khilya, I. P. Yanchuk, L. Ya. Shtanova, S. P. Vesеlsky, T. V. Vovkun, O. V. Tsymbalyuk, V. S. Moskvina, O. V. Shablykina, S. L. Bogza The evaluation of 2.3-diazepine influence on tissue respiration of the liver and its exocrine function in rats with a rotenone model of Parkinson’s disease Biopolym. Cell. 2019; 35(5):356-370