Welcome to the Advanced Organic Synthesis Laboratory — a modern research center specializing in the development of innovative methodologies for the reduction of organic compounds. We offer cutting-edge technologies for efficient and environmentally friendly organic synthesis.
Our Technologies and Equipment
- High-temperature reactors for hydrogenation.
- Electrochemical systems for the reduction of organic molecules.
- Catalytic flow systems for precise and efficient chemical transformations.
- Autoclaves for high-pressure reactions (volume from 0.15 to 3 L, temperature up to 200°C, pressure up to 150 atm) from leading manufacturers: Riva-Stal (RVD-2-150 — RVD-3-3000) and Berghof-3000.
Main Research Areas
Metal-Catalyzed Hydrogenation
Under the supervision of Senior Researcher Yurchenko O.O., studies are conducted on the use of palladium, platinum, and nickel catalysts for the selective reduction of carbonyl, nitro, and alkene functional groups. The most commonly performed reaction is hydrogenation on heterogeneous catalysts:
- Raney Nickel
- Palladium, rhodium, ruthenium on activated carbon or alumina gel
- A unique metal deposition method on a carrier surface with a concentration of 0.5–1% (more cost-effective than traditional catalysts with metal concentrations up to 10%)
- Utilization of rhenium sulfide for the hydrogenation of aromatic rings in thiophenes, benzothiophenes, and quinolones.
Nucleophilic Substitution of Active Halogens
The laboratory actively researches nucleophilic substitution reactions, particularly for amines with low boiling points that require closed-system processing at high temperatures.
Organocatalytic Reduction
We offer environmentally friendly alternatives to traditional reduction methods, including:
- Hydrogen transfer methods that minimize waste generation
- Optimization of reaction conditions to enhance selectivity and efficiency
Scientific Collaboration and Innovation
The laboratory actively collaborates with academic institutions and industrial partners to develop scalable protocols for fine chemical synthesis. We employ advanced analytical techniques, including IR, NMR, and UV-Vis spectroscopy, to monitor reactions and ensure high process accuracy.
Safety and environmental sustainability are essential aspects of our work. We focus on the development of eco-friendly reagents and the optimization of reaction conditions to minimize environmental impact.
With a multidisciplinary approach, our laboratory continues to push the boundaries of organic synthesis, making significant contributions to the advancement of medicinal chemistry, materials science, and industrial technologies.