Head of department
Ph.D., prof. P.P. Onysko

The department’s research focuses on the following priority areas: developing scientific foundations for creating highly reactive building blocks, used as core structures in the synthesis of compounds with specified structures and biological activities. exploring new strategies for synthesizing biorelevant derivatives of aminophosphonic and aminocarboxylic acids, utilizing iminophosphonates and iminocarboxylates as key intermediates. investigating new unsaturated systems to develop acyclic, alicyclic, and heterocyclic compounds with practical applications. Creating efficient methodologies for the stereoselective synthesis of optically active compounds containing pharmacophore groups.

The department also conducts research on highly electrophilic functionalized imines and their application in the asymmetric synthesis of fluorine-containing aminocarboxylic and aminophosphonic acids. Additionally, efforts focus on developing synthetic approaches to fluoroalkyl-substituted aminocycloalkanes of various ring sizes, which serve as promising building blocks for designing compounds for medicine and agrochemistry.

Main Scientific and Practical Achievements of the Department

The department has made several fundamental contributions, including the formulation of principles for constructing element-substituted heteroallyl and heterodiene systems prone to rearrangements. These involve the migration of protons, chlorine, phosphorus, sulfur-containing, and unsaturated groups. Research into unsaturated electrophilic systems has uncovered new transformations, such as the 1,3-H isomerization of iminoalkylphosphonates, mimicking biochemical transamination.

Key achievements include: Introducing new reactive phosphorylated imines and azadienes into organic synthesis. Developing a novel strategy for synthesizing acyclic and heterocyclic derivatives of aminophosphonic, diphosphonic, aminocarboxylic, and unsaturated aminophosphonic acids. These compounds are essential in the design of potential HIV protease inhibitors, antimicrobial agents, and antiviral drugs. Creating a method for interconverting biologically important α-keto- and α-aminophosphonic acids based on proton transfer in diphosphorylated azapropenes.

Synthesizing previously unknown fluorinated NH iminophosphonates and iminocarboxylates, valuable as low-molecular-weight building blocks for organic and asymmetric synthesis, and for incorporating pharmacophore fluoroalkylated aminocarboxylic and aminophosphonic moieties into various structures. These also facilitate the preparation of fluoroalkylated amino acid derivatives, their phosphorus analogs, and biomimetics.

Developing new chiral building blocks containing fluorinated amino acid fragments or their phosphorus analogs, which have potential for biomedical applications. Synthesizing novel photoactive glutathione S-transferase inhibitors based on α-ketophosphonic acid derivatives, promising for photo-dependent drug development. Establishing effective methodologies for synthesizing five-, six-, seven-, and eight-membered azaheterocycles, which combine pharmacophore endocyclic sulfonamide moieties with (poly)fluoroalkyl groups, using new 1,3-CNS bielectrophilic agents.

Developing methods for synthesizing fluoroalkyl-substituted cyclopropyl-, cyclobutyl-, and cyclopentylamines, fluorinated azacyclopentanes, and conformationally rigid bicyclic pyrrolidine derivatives. These compounds represent unique building blocks with significant potential in organic synthesis and biomedical research.

Creating new approaches for synthesizing mono- and bicyclic systems with various ring sizes and a boropinacolate function in the nodal position, based on boron-containing synthons. Developing an eco-safe mechanochemical methodology for introducing new functional groups, including fluorinated ones, into molecules and transforming them.

Creating efficient methods for producing previously unknown or hard-to-access fluorinated aldehydes, ketones, and carboxylic acids through photochemical reactions of inhalation anesthetics such as 1,1,1-trifluoro-2-chloro-2-bromoethane (Fluorothane, Halothane) and the fire-extinguishing agent 2,2-dibromotetrafluoroethane (Halon 24). These compounds have significant potential for use in organic synthesis and medicinal chemistry. A convenient method has been developed for the synthesis of trifluoromethylated analogues of glibenclamide, a widely used drug for treating type 2 diabetes.

Theoretical advancements in anionic α-complexes of phosphorus compounds and polynitro compounds have led to the creation of a new methodology for neutralizing explosives. This process transforms explosives into practically useful compounds such as functionalized nitrogen-containing heterocycles, 1st-3rd generation dendrons, and calixarene dendrimers, which can be used as complexing agents and molecular sensors.

Highly effective plant growth regulators that boost the yield of melon and vegetable crops ("Triamelon"), as well as cereals and potatoes ("Simarp"), have been successfully implemented in agricultural practices. Fluorinated analogues of the anti-cancer drug fotemustine have been synthesized and patented, offering potential new avenues for cancer treatment.

A new powerful inhalation anesthetic, cis-1,2-bis(trifluoromethyl) cyclopropane, has been developed, enhancing options for medical anesthesia. New diene hydrocarbon stabilizers, epoxy resin modifiers, and a catalyst for the production of polyurethane foams and specialized materials have been developed, advancing the field of material science and industrial chemistry.

Employees of the department:

  • Head of the department, Sc.D., prof. Petro Onys’ko
  • Leading researcher, Sc. D., prof. Yuliia Rassukana
  • Senior researcher, Ph. D., Svitlana Shishkina
  • Senior researcher, Ph. D., Yurii Pustovit
  • Senior researcher, Ph. D., Andrii Bezdudnyi
  • Senior researcher, Ph. D., Olexandr Shalimov
  • Researcher, Ph. D., Liudmyla Bezgubenko
  • Researcher Anatolii Alekseenko
  • Juinior researcher, Ph. D. Ivanna Yelenich
  • Juinior researcher, Ph. D. Alona Cherednichenko
  • Juinior researcher, Ph. D. Oksana Shavrina
  • Juinior researcher, Ph. D. Anastasiia Aleksandrova
  • Leading engineer, Ph. D. Ihor Kleban
  • Leading engineer Tetiana Chudakova
  • Engeneer of the 1st category Yaroslav Syzonenko
  • Engeneer Roman Zakharko
  • 1st category technician Kateryna Fetesku

Current projects (public financing):

DEVELOPMENT OF SCIENTIFIC PRINCIPLES FOR THE CREATION OF ELEMENT SUBSTITUTED REACTIVE SYNTHONS AS BASIC STRUCTURES IN THE SYNTHESIS OF COMPOUNDS WITH PRACTICALLY USEFUL PROPERTIES

CREATION OF ELEMENT-CONTAINING BUILDING BLOCKS FOR THE NEEDS OF ORGANIC SYNTHESIS, MEDICAL CHEMISTRY AND AGROCHEMISTRY

Competition projects (public financing):

CREATION OF EFFECTIVE APPROACHES TO CONSTRUCTING HETEROATOMIC AND HETEROCYCLIC STRUCTURES FOR BIOMEDICAL RESEARCH AND NEW FUNCTIONAL MATERIALS

PREDICTION OF BIOACTIVITY AND CREATION OF MODERN APPROACHES TO THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS FOR THE NEEDS OF THE PHARMACEUTICAL INDUSTRY. CHAPTER 1. DEVELOPMENT OF PROSPECTIVE MOLECULAR PLATFORMS FOR THE NEEDS OF MODERN MEDICINAL CHEMISTRY BASED ON NITROGEN HETEROCYCLES, SUPRAMOLECULAR COMPOUNDS AND GLYCOSIDES

CREATION OF FLUORINE AND PHOSPHORUS-CONTAINING BUILDING BLOCKS, INCLUDING OPTICALLY ACTIVE ONES, FOR THE NEEDS OF MEDICAL CHEMISTRY AND AGROCHEMISTRY

Scientific cooperation:

  • Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
  • V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
  • Taras Shevchenko National University of Kyiv
  • Uzhhorod National University
  • National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
  • State Scientific Institution «Institute for Single Crystals» of National Academy of Sciences of Ukraine
  • «Farmak»
  • «Ukrorgsyntez», Kyiv

Articles for 2021-2024

  1. Yu.V. Rassukana, P.P. Onysko C-phosphorylated imines in synthesis of non-racemic α-fluoroalkylated aminophosphonic acid derivatives // Phosphorus Sulfur Silicon Rel. Elem. 2022, 197, 444-450
  2. Yu.V. Rassukana, A.S. Cherednichenko, S.V. Shishkina, P.P. Onys’ko Enantiomeric N-(tert-Butylsulfinyl) Polyfluoroalkyl Aldimines in aza-Henry Reaction: Effective Route to Chiral Polyfluoroalkyl Nitroamines and Diamines // Eur. J. Org. Chem. 2023, 26, e202300607
  3. P. Onysko, Y. Syzonenko, O. Shalimov Interconversion of Aminophosphonates via Biomimetic 1,3-H Transfer in 1,3-Diphosphorylated Azapropenes // Universal J. Green Chem. 2023, 1, 1-8
  4. O. Shalimov, M. Kolotylo, D. Otsaliuk, S. Shishkina, O. Muzychka, P. Onys'ko Efficient Synthesis of Fused Heterocycles Incorporating Pyrazole/Thiadiazine or Pyrazole/Thiadiazepine Fragments Using N-Chlorosulfonyltrihaloacetimidoyl Chlorides // ChemistrySelect, 2023, 8, e202302929
  5. O.M. Shavrina, Yu.V. Rassukana, P.P. Onysko Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived Heterocycles through Direct Fluorination // Curr. Org. Synthesis, 2024, 21, 1053-1074
  6. Yu.V. Rassukana, A.M. Aleksandrova, L.V. Bezgubenko, P.P. Onys'ko Effective and Scalable General Method for the Preparation of Enantiomeric (α-Aminoalkyl)dimethylphosphine Oxides // ChemistrySelect, 2024, 9, e202400146

The Major Scientific and Practical Achievements of the Department

Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department Department of organoelement chemistry - The Major Scientific and Practical Achievements of the Department