Head of the department: DSc, Professor, Corresponding Member of NAS of Ukraine Vovk M.V.
Head of the department:
DSc, Professor, Corresponding Member of NAS of Ukraine Vovk M.V.

The department was organised in 1947 by Academician of the National Academy of Sciences of Ukraine E.O. Shilov, who headed it until 1973. In 1973-2009, the department was headed by Doctor of Chemical Sciences, Professor V.I. Staninets. Since 2009, the department has been headed by Doctor of Chemical Sciences, Professor M.V. Vovk. In 2022, the department was renamed the Department of Chemistry of Functional Heterocyclic Systems. The department has 1 doctor, 11 candidates of chemical sciences, 2 doctors of philosophy and 4 engineers. There are 3 postgraduate students working on their PhD theses.

Mykhailo Vovk conducts systematic studies of electrophilic and oxidative cyclisation reactions, organo- and photocatalytic processes of acyclic and heterocyclic systems, methods of synthesis and properties of polyfunctional mononuclear and condensed heterocyclic structures, and rational search for pharmacologically promising compounds. In 2009, M.V. Vovk was awarded the title ‘Inventor of the Year of the National Academy of Sciences of Ukraine’, in 2017 he was awarded the Kiprianov Prize of the National Academy of Sciences of Ukraine, and in 2020 - the State Prize of Ukraine in Science and Technology. M.V. Vovk is the author and co-author of 660 publications, including 6 textbooks and monographs, 48 scientific reviews, 536 articles and 70 patents. He has trained 5 Doctors, 17 Candidates of Chemical Sciences in Organic Chemistry and 1 Candidate of Pharmaceutical Sciences in Pharmaceutical Chemistry and Pharmacognosy, 4 Doctors of Philosophy in Chemistry.

The main scientific direction of the department is the research on the reactions of heterocyclisation of bicentric organic substrates; development of effective methods for the synthesis of polyfunctional heterocyclic systems, including structural analogues of natural compounds; use of organo-, metal- and photocatalytic processes for the design and modification of heterocyclic compounds; search for ligands of heterocyclic structure for bio-oriented metal complexes; rational design of bioactive compounds with a wide pharmacological profile.

Main scientific and practical achievements of the department

Methodological principles for the design of new types of azole-azole, azole-azine and azole-azepine compounds, structurally modified with linear-functional and heteroanelated fragments have been developed, which are promising for organic synthesis and biomedical research. Heterocyclic systems containing chalcogenide, halogenoalkyl, formyl, carboxyl, alkenyl, alkynyl, amino and hydrazine groups, which are key for further structural modifications, were synthesised. The known and new, primarily catalytic, methods of functionalisation and anilisation of small and medium heterocyclic nuclei to basic azole and azine templates were significantly improved. The regularities of regio- and stereocontrol in the implementation of highly selective cyclization methods for the directed synthesis of condensed heterocyclic compounds as molecular platforms for the design of bioactive substances were established. The results of the biological screening allowed us to identify compounds with pronounced antimicrobial, anti-inflammatory and antioxidant properties among the functional derivatives of heteroanelated azoles, azines and azepines.

Employees of the department

  • the head of the department, Doctor of Science, prof., Corresponding Member of NAS of Ukraine Mykhailo V. Vovk
  • senior researcher, PhD Yurii L. Zborovskii
  • senior researcher, PhD Ruslan I. Vaskevych
  • senior researcher, PhD Viktor V. Orysyk
  • senior researcher, PhD Andriy V.
  • senior researcher, PhD Bol'but
  • senior researcher, PhD Alla I. Vaskevych,
  • senior researcher, PhD Anton V. Bentya
  • senior researcher, PhD Victor M. Tkachuk
  • researcher, PhD Nazar M. Tsyzoryk
  • researcher, PhD Sergiy V. Kemskiy
  • researcher, PhD Mariia B. Litvinchuk
  • senior researcher, PhD Ivanna Yu. Danyliuk
  • engineer Natalia G. Chubaruk
  • engineer Oleh O. Lukianov
  • engineer Nataliia O. Savinchuk
  • Engineer Natalia A. Syrota
  • Engineer Yaroslav I. Nechesnyi
  • Engineer Khrystyna I. Loza
  • 1st rank technician Anna O. Lisova

Articles for 2021-2024:

  1. Vaskevych A., Dekhtyar M., Vovk M. Cyclization of Alkenyl(Alkynyl)-Functionalized Quinazolines and their Heteroanalogues : a Powerfull Strategy for the Construction of Polyheterocyclic Structures Chem. Record 2024, vol.24, N2, e202300255
  2. Danyliuk I.Yu.,Kemskyi S.V.,Polishchuk V. M.,,Shishkina S.V., Vovk M.V. Visible-light-induced photocatalitic iodo(per)fluoroalkylation of 5-amino-N-allyl-1,2,3-triazole-4-carboxamides J. Fluor. Chem. 2024, vol. 276, N 110292
  3. Koidan G., Tsyzoryk N., Rusanov E.B., Shishkina S.V., Vovk M. Kostyuk A. Functionalization of Position 7 of Pyrazolo[1,5-a]pyrazines SynOpen, 2024, N 8, p. 130-137
  4. Kemskyi S., Grozav A., Chornous V., Yakovychuk N., Fedoriv M., Mel’nyk D., Melnyk O., Vovk M. Synthesis, antimicrobial activity, DFT-calculation, and docking of 4-(1,3,4-thiadiazol-2-yl)-containing polysubstituted pyrroles Curr. Chem. Lett. 2024, vol.13, N 4, p.761-776
  5. Vaskevych A., Shishkina S., Dekhtyar M., Smolii O., Vovk M. Access to Seleno-Functionalized Thiazolo[3,2-a]Pyrimidinones and Pyrimido[2,1-b][1,3]Thiazinones via Selenocyclization of 2-Alkenylthio-pyrimidinones and Their Fused Analogs Chem. Select 2024, vol.9, N 36, e202403699
  6. Vaskevych A.I., Vovk M.V. Thiofunctionalized ℽ-lactams Heterocycles,2023, vol. 106, N 9, p.1478-1513
  7. Kemskyi S., Fedoriv M., Palamar A., Grozav A., Chornous V., Kutsyk R., Dorokhov V., Vovk M. Synthesis and evaluation of antimicrobial activity of some 3-(pyrrol-4-yl)acrylamide derivatives Curr. Chem. Lett. 2023, vol.12, N 3, 519-528
  8. Vaskevych A.I., Savinchuk N.O., Vaskevych R.I., Shishkina S.V., Vovk M.V. Pd-catalyzed oxidative amination of 2-alkenylquinazolin-4(3H)-ones : senthesis of methylene and vinyl derivatives of pyrrolo(pyrido)[2,1-b] quinazolinones Org. Biomol. Chem. 2023, vol. 21, p.5866-5872
  9. Litvinchuk M.B., Bentya A.V., Grozav A.M., Yakovychuk N.D., Palamar A.M., Saliyeva L.M., Shishkina S.V., Vovk M.V. Synthesis, antimicrobial and antioxidant activity of novel 1-oxo-1,2,3,4-tetrahydropyrrolo- [1,2-a]-pyrazine-8-carboxylic acids, esters, and amides thereof Monatsh. Chem. 2023, vol.154, N10, p.1145-1154
  10. Chornous V., Grozav A., Vovk M., Bratova D., Kasian N., Lisetski L., Gvozdovskyy I. Oblique helicoidal stste of the twist-bend nematic doped by chiral azo-compound Liquid Crystals, 2023, vol.50, N 6, p. 1046-1058
  11. O. Lukianov, V. Tkachuk, S. Shishkina, L. Lachmann, O. Vadzyuk, P. Borysko, D. Kovalskyy, I. Gillaizeau, V. Sukach Hydroaminoalkyl Functionalization of Pyrimidin-2(1H)-ones by Visible Light Organophotocatalysis: A Radical Approach to Biginelli-Type Dihydropyrimidines Adv. Synth. Catal. 2023, Vol. 365 (20), pp. 3484-3492
  12. Vaskevych A.I., Savinchuk N.O., Vaskevych R.I., Rusanov E.B., Vovk M.V. Chalkogenation/pyrrolo(pyrido)annulation of 2-(3-butenyl)quinazolin-4(3H)-ones by arylsulfenyl(selenyl) chlorides Tetrahedron, 2022, v.111, art. 132722
  13. Stasevych M., Zvarych V., Yaremkevych O., Vovk M., Vaskevych A., Halenova T., Savchuk O. N-(9,10-Dioxo-9,10-dihydro-antracen-1(2)-yl)-2-(R-thio) Acetamides : Synthesis, Antioxidant and Antiplatelet Activity Acta Chim. Slov. 2022, 69, 3, 584-595
  14. Zvarych V., Stasevych M., Rusanov E., Vovk M. A Ring Opening-Annulation on Reaction of Anthra[1,2-d][1,2,3]-triazine-4,7,12(3H)-trione іn the Presence of Pyridines as an Efficient Approach to the Construction of Naphto[2,3-H]pyrido(quinolino)-[2,1-b]quinazoline System Molecules, 2022, vol. 27, N 18, 5927
  15. Grozav A.M., Chornous V.O., Diichuk I.V., Yakovychuk N.D., Fedoriv M.Z., Vovk M.V. Synthesis and biological evaluation of O-acyloximes of 5-chloro-4-formyl-1H-pyrrol-5-carboxylates as antimicrobial agents Biopolim. Cell. 2022,38(1), 48-57
  16. Chornous V., Vovk M., Bratenko M., Dmytriv Yu., Rudnichenko A., Skorobahatko M., Kasian N., Lisetski L., Gvozdovskyy I. Light-controllable chiral dopand based on azo-fragments : synthesis and characterisation Liquid Crystals, 2022, 49, 10, 1322-1337
  17. Litvinchuk M.B., Bentya A.V., Rusanov E.B., Vovk M.V. Activated 2-methylidene-1,3-thiazo-lidin-4-ones in a promising approach to the synthesis of polyfunctional thiazolo[3,2-c]pyrimidines Monatsh. Chem. 2021, 152, 1261-1268
  18. Orysyk S., Baranets S., Borovyk P., Palchykovska L., Zborovskii Yu., Orysyk V., Likhanov A., Platonov M., Kovalskyy D., Shyryna T., Danylenko E., Hurmach V., Pekhnyo V., Vovk M. Mononuclear π-complexes Pd(II) and Pt(II) with 1-allyl-3-(2-hydroxy-ethyl)thuiourea: synthesis, structuta, molecular docking, DNA binding ability and genotoxic activity Polyhedron, 2021, 210, art. 115477
  19. Vaskevych A.I., Savinchuk N.O., Vaskevych R.I., Rusanov E.B., Grygorenko O.O., Vovk M.V. The PIFA- initiated oxidative cyclization of 2-(3-butenyl)quinazo-lin-4(3H)-ones – an efficient approach to 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones Beilst. J. Org. Chem. 2021, N 17, p. 2787-2794
  20. Kolodyazhna T.I., Lega D.A., Suikov S.Yu., Kyrylchuk A.A., Vovk M.V., Chernykh V.P., Shemchuk L.A. Some Aspects of 4H-Pyrans Synthesis Based on 4-Chloro-1-ethyl-1H-benzo[c][1,2]thiazine-3-carbaldehyde 2,2-dioxide: Antimicrobial Activity of the Compounds Synthesized Сhemistry Select, 2021, vol.6, N 48, p. 14005-14012
  21. Danyliuk I.Yu., Vaskevich A.I., Vaskevich R.I., Rusanov E.B., Vovk M.V. Cyclosulfenylation of N-(1(2)-naphthyl atyrylacetamides as a synthetic route to 4(2)-arylthio naphto[1,2-b]([2,1-b])azepin-2(4)-ones J. Sulf. Chem. 2021, vol.42, N 3, p. 264-280
  22. Tkachuk V.M., Lukianov O.O., Vovk M.V., Gillaizeau I., Sukach V.A. Chan-Evans-Lam N1-(het)arylation and N1-alkenylation of 4-fluoro alkylpyrimidin-2(1H)-ones Beilst. J. Org. Chem. 2020, 16, 2304-2313
  23. Vaskevich R.I., Vaskevich A.I., Rusanov E.B., Mel’nyk O.Ya., Vovk M.V. Synthesis of new type 1,3,6-triazocyne via intramolecular reactions of iodocyclization and [3+2] azido cycloaddition J. Heterocycl. Chem. 2020, v.57, N8, p. 3202-3212
  24. Yakovenko G.G., Lukianov O.O., Yagodkina-Yakovenko M.S., Bol’but A.V., Vovk M.V. Synthesis of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives and annulation of imidazole and pyrimidine rings thereto Chem. Heterocyclic Compd.,2020, 56, N3, p.347-354
  25. Litvinchuk M.B., Bentya A.V., Slyvka N.Yu., Rusanov E.B., Vovk M.V. A convenient method of synthesis of 8-acyl-2,3,6,7-tetrahydro-5Н-[1,3]thiazolo[3,2-c]pyrimidin-5-ones Chem. Heterocyclic Compd., 2020, 56, N1, p.101-107
  26. Danyliuk I.Y., Vaskevich R.I., Vaskevich A.I., Suikov S.Y., Rusanov E.B., Chornous V.O., Vovk M.V. Synthesis of naphto[1,2-b]-, naphto-[2,1-b]-, and naphto[2,3-b]azepino-nes via proton-induced cyclization of N-1(2)-naphthyl styrylacet-amides J. Heterocycl.Chem. 2020, v.57, N1, p. 317-326
  27. Melnykov S., Sukach V., Vovk M. Recent Achievements in Nucleophilic Decarboxylative Addition Reactions Curr. Org. Chem. 2020, 24 (19), 2193–2215